Case - ?lipid storage

Male 12 year, presented with severe anemia, moderate splenomegaly, moderate hepatomegaly, PS shows microcytic hypochromic anemia (Hb 3.5), with rouleaux formation, platelet low normal, total count appear low normal with neutrophils 70%. BM examination done 3 days after first BT given on the day of admission. cilincally ??acute leukemia. On bone marrow, there was mild erythroid hyperplasia, prominent toxic granulation in neutrophilic precursors. No significant number of blasts. Megakaryocytes appear within normal limits. Now after almost ruling out acute leukemia, second clinical possibility remains is of ?lipid storage or ?some chronic infection. I am posting few pictures here, does it suggest any storage disorder or just arteffects. Kindly give your opinions. I feel it is some chronic infection, but not sure. MP negative by slide and card. Kindly give your comments. Will try to post more pictures soon.

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spot it -8: answers

As indicated in comments, first one is aspergillus, with relatively uniform diameter and 45 degree branching ( acute angle branching), second one is mucormycosis having variable diameter of hyphae and mostly 90 degree branching

Spot it-8

Identify this two different fungi

Spot it-7 :answer

Both images are of budding yeast forms, first one shows tear drop shaped budding suggestive of cryptococcus, while second image shows broad based budding suggestive of blastomycosis.

Spot it-7

Identify this two fungus, you can give your comments

Spot it 6: answer

Though they look like but these cells are NOT squamous cells. If we see carefully these cells are having geometric profiles, many have square or quadrangular appearance, characteristic feature of plant cells, contaminating the specimen.

Spot it 6

This is a image from sputum, a very interesting one, can you identify this cells??
I will post answer after two days

Spot it 5: Answer

This image is of Toxoplasma myocarditis, showing encysted bradyzoites of Toxoplasma gondi

Spot it-5

This image is from heart

Spot it 4: Answer

Hi friends, this picture is of embryoid body from polyembryoma, a type of mixed germ cell tumor in which embryonal and yolk sac component combine to form structure resembling developing embryo (embryoid body)

Spot it-4

Image from Ovary

Spot it-3: Answer

Both are benign,

First figure shows radiation change, enlarged cells with low N:C ratio and smudgy chromatin is typical of radiation change

Second figure shows degenerative change, as evident by karyorrhexis

Spot it-3: benigh or malignant

This two are bronchial brush PAP stained preparation from different cases, what do you think are they benign or malignant? give your comments separately for both images.

Correct answer will be posted after 2 days

Spot it 1 and 2- answer

Spot it 2: these are charcot layden crystals in sputum, formed due to disintegration of eosinophilic granules , they can be seen in allergic pulmonary conditions including asthma



Spot It- This are sputum images showing curschmann spiral , they can be considered as mucus casts formed in bronchioles due to obstruction, can be seen in asthma, chronic smokers and other causes of obstruction

Spot it-2

Give your comments, I will post correct answer after 2 days

Spot It!

Hi, friends give your comments on this picture, correct answer will be posted after 2 days