Wednesday, December 30, 2009

Severe Swine Flu ( H1N1 ) cases and asthma are linked

When swine flu emerged last spring, disease trackers warned that children and adults with underlying medical conditions would be especially susceptible to the ravages of the virus.

Now, a review of disease surveillance records by Massachusetts health authorities has found that one chronic condition is far more common than any other among patients hospitalized with H1N1 infections: asthma.

The persistent respiratory ailment, which has become strikingly more prevalent in recent decades, was present in 31 percent of swine flu patients who entered Massachusetts hospitals already suffering from longstanding health problems. By comparison, 6 percent of those swine flu patients had heart problems, and 6 percent had kidney disease.

The finding provides fresh evidence of the toll influenza exacts on people whose ability to breathe is already compromised. And it led specialists this week to reinforce their admonition that patients with asthma, chronic obstructive pulmonary disease, and other respiratory conditions should be vaccinated against H1N1 as well as the seasonal strain.

Sunday, December 27, 2009

Vitamin C slows ageing


Touted as a remedy for common cold, Vitamin C has also shown promise in slowing down the ageing process. A study has shown that it facilitates output of embryonic-like stem cells from adult cells.

Over the past few years, it has been known that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes.

Most embryonic stem cells are derived from embryos that develop from eggs fertilised in vitro in a fertilisation clinic.

Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.

"The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it," explains Duanqing Pei, senior author of a new study on the subject.

"Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated," explains Pei from South China Institute for Stem Cell Biology and Regenerative Medicine.

Researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells.

Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state, said a release of the South China Institute.

Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.

One liver, two recipients

CHICAGO - Doctors at Chicago's Children's Memorial Hospital say they successfully performed transplants on two patients using segments from the same liver.

The operations Friday were a first for the hospital. Split-liver transplants are rare and technically challenging.

The eight-hour operations were performed on 2-year-old Frank Sroka and 17-year-old Christian Liberto.

The hospital says both boys are doing well. The younger child had a disease that blocks the bile ducts. The teenager had a rare chronic liver disease.

A piece of a healthy liver can grow into a whole organ in about a month.

Friday, December 18, 2009

Clues found why H1N1 virus kills

An international study has found a molecule in H1N1, or swine flu, patients whose levels determine the severity of the illness or even death.

Canadian and Spanish scientists have found this molecule called Interleukin 17 (IL-17) to be the first potential immunological clue of why some people develop severe pneumonia when infected by the H1N1 virus. The study was carried in 10 Spanish hospitals during the first pandemic wave in July and August this year.

Researchers from the Hospital Clinico Universitario de Valladolid in Spain, Toronto's University Health Network and the University of Toronto analysed different levels of regulating molecules (IL-17) for 20 hospitalized patients, 15 outpatients and 15 others.

They found high levels of IL-17 molecule in the blood of severe H1N1 patients and low levels in patients with the mild form of the disease.

According to a statement by the University of Toronto, IL-17 is produced by the body and is important in the normal regulation of white blood cells which fight infection and disease.

But in certain circumstances, the molecule becomes out of control, leading to inflammation and autoimmune diseases like H1N1.

The research paper titled 'Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza,' has been published in the December issue of the Journal of Critical Care.

"In rare cases, the virus (molecule) causes lung infections requiring patients to be treated in hospital. By targeting or blocking Th17 in the future, we could potentially reduce the amount of inflammation in the lungs and speed up recovery,'' Canadian professor David Kelvin, who was part of the research team, said.

Kelvin said the clinical applications of their study will take some time. But a test to determine who has high levels of this molecule is possible in the near future, he said.

"A diagnostic test could let us know early who is at risk for the severe form of this illness quickly,'' the Canadian said.

The high levels of the molecule would indicate a failure of the immune system to eliminate the virus, similar to what happened during the 1918 Spanish flu when a deadly influenza A virus strain of sub-type H1N1 ravaged populations, he added.

The statement also quoted Dr Jesus Bermejo-Martin of the Spanish team as saying that identifying drugs that regulate the activity of IL-17 may provide alternative treatments for patients with severe H1N1.

Wednesday, December 16, 2009

93% deprived of sleep, 11% fall asleep at work: Study

Ninety three percent Indians are sleep deprived and get less than the eight hours of mandatory sleep required for good health while 11 percent actually fall asleep at work, says a latest survey.

Eleven percent Indians took leave from work because of lack of sleep, according to the survey commissioned by Philips Electronics India Limited.

The survey conducted by Nielsen company in November 2009, covered 5,600 respondents in the 35-65 age group across 25 cities in urban India with a population of five lakh plus.

Fifty eight percent of the respondents felt that their work was impacted due to lack of adequate sleep with 11 percent falling asleep at work.

74 percent woke up anywhere between one to three times during their sleep. Reasons for waking up were need to answer call of nature (90 percent), stress at work (15 percent) and noise outside the home (10 percent).

Sixty two per cent of those surveyed displayed high risk of Obstructive Sleep Apnea (OSA), a condition characterised by repeated cessation of breathing during sleep and which can potentially lead to heart diseases and worsen heart failure.

Monday, November 30, 2009

Docs told not to accept gifts from drug cos

The global association of doctors World Medical Association (WMA) has asked physicians to refrain from taking gifts, including hard cash from drugmakers, as an incentive to promote their medicines to the patients. It is part of a resolution passed by WMA outlining the guidelines for doctors to follow while dealing with pharma companies.

The advisory issued during a recent WMA meeting in Delhi comes at a time when the domestic pharma companies and medical bodies are in the process of finalising a detailed marketing code of conduct to curb the practice of pharma companies paying doctors to prescribe their medicines. The Indian government had recently asked the drug industry to self regulate so that the interests of the patients are not compromised.

The Rs 36,000-crore Indian drug retail market is fiercely competitive, with the largest player having a meagre 5% market share. Globally, drugmakers are not allowed to advertise their prescription drugs, or medicines that can only be bought on a doctors prescription. As a result, the success of a medicine largely depends on the recommendation of doctors.

The WMA guidelines has asked doctors to refrain from taking expensive personal gifts designed to influence clinical practice, payments in cash or cash equivalents from companies, payment to cover travelling expenses or room for conference or compensation for their time, and declare financial support they get from companies.

The Indian Medical Association (IMA), representing doctors in the country, and the domestic drugmakers associations say they agree with the WMA resolution in-principle. IMA secretary general Dharam Prakash said: “Once you take a gift or travel at somebody’s expense, you would be obliged to return the favour, which means promoting a company’s brand. The resolution should curtail the practice of drugmakers to unethically promote their drugs.”

“In many areas, the WMA statement is similar to our code of conduct for marketing practices. This is a good step in the right direction,” said Tapan Ray, director general at the Organisation of Pharmaceutical Producers of India, a group that represents the interests of large drugmakers in the country.

Most doctors in the country accept gifts and incentives in various forms to promote a particular company’s products. Industry experts such as CM Gulati, a veteran with medical regulations, feels the resolution will be ineffective and it is an attempt by the medical fraternity and industry bodies to prevent the government from regulating the drugmakers marketing practice.

“Both the doctor and industry are interested parties who benefit from the current practice, the consumers interest is not represented. The industry bodies are toothless and can’t take any punitive action, so the question of self-regulation is a hogwash,” he says.

Saturday, November 21, 2009

Changes Recommended in Schedule of Cervical Cancer Screening

Less than a week after a government task force announced controversial recommendations for breast cancer screening, a doctor's group is recommending big changes in cervical cancer screening.

The American College of Obstetricians and Gynecologists (ACOG) now says women should begin cervical cancer screening at age 21, rather than earlier in life.

And the group no longer recommends annual screening for most women.

The new breast cancer recommendations sparked heated debate within the medical community. Even those who support delaying the onset of mammography screening acknowledge that some breast cancers will be missed.

But experts tell WebMD the revised cervical cancer guidelines will not be as controversial.

"The new recommendations for cervical cancer screening really do not miss any cancers," says David E. Soper, MD, who chairs ACOG's Gynecological Practice Bulletin Committee.

"The data are very clear," he tells WebMD. "For women in their 20s, having an annual Pap smear will find no more cancers than screening every two years."

Pap Test Saves Lives

Soper says the call for delayed and less frequent screening does not mean Pap testing is not effective.

Screening is largely responsible for a 50% decline in cervical cancer rates during the past three decades.

"There are still 11,000 new cases of cervical cancer and 4,000 cervical cancer deaths in the United States each year, and most of these could be prevented with adequate screening," Soper says.

ACOG now recommends:

  • Screening women with Pap testing between the ages of 21 and 30 every two years instead of annually
  • Screening women 30 and older who have had three consecutive normal Pap test results every three years instead of annually
  • More frequent screening for women with risk factors for cervical cancer

Screening can be stopped in women who are 65 to 70 and have had three or more consecutive normal test results and no abnormal test results in the past 10 years.

Women who have been vaccinated against human papillomavirus ( HPV) should follow the same screening guidelines as unvaccinated women.

Even if a Pap test isn't due, doctors should let their patients know that annual gynecologic exams may still be appropriate.

The Case Against Screening Teens

ACOG's previous guidelines called for cervical cancer screening to begin three years after a woman becomes sexually active or by age 21, whichever occurs first.

Many women become infected with sexually transmitted HPV, but most women's bodies get rid of the infection naturally. Most women who get infected don't develop cervical cancer, and there are other causes of cervical cancer.

But while active infection can be common in women younger than 21, cervical cancer is remarkably rare.

"It literally occurs in about one in a million women younger than 21," Soper says.

Since about 85% of women who become infected will clear the HPV virus within a few years, delaying screening until age 21 will prevent unnecessary surgical treatment to remove suspicious lesions.

Such treatment has been linked to an increase in premature births.

"Screening for cervical cancer in adolescents only serves to increase their anxiety and has led to overuse of follow-up procedures for something that usually resolves on its own," ACOG's Alan G. Waxman, MD, says in a news release.

Ob-gyn Mark H. Einstein, MD, agrees. He directs the division of gynecologic oncology clinical research program at New York's Montefiore Medical Center.

"The vast majority of abnormalities identified though early screening are clinically irrelevant manifestations of [transient] HPV infection," he tells WebMD. "Early screening stigmatizes young women and subjects them to extra testing and unnecessary treatment."

Perspective of American Cancer Society

The American Cancer Society, which was highly critical of the mammography changes, supports the new ACOG cervical cancer guidelines.

Last June, representatives from the American Cancer Society, ACOG, and close to 25 other health groups met to discuss cervical screening and management for adolescents.

According to American Cancer Society Director of Breast and Gynecologic Cancer Debbie Saslow, PhD, there was general agreement that for most women, screening should begin at age 21.

Saslow says in a news release that overscreening has lead to overtreatment of young women. But she also says that underscreening of women who should have regular Pap tests leads to death. "Most women who die from cervical cancer have never been screened or have not been screened in at least five years."

stem cell transplant for thalassemia

Exactly 49 days ago, Harshil Nanda was a severely ill thalassemic patient with B positive blood group. Today, he is a healthy infant with A positive blood group and a confirmed evidence of how stem cell transplant can cure thalassemia.

The change in his blood group is in fact proof that Harshil’s procedure, the country’s second stem cell transplant from umbilical cord blood of a stranger child received from a private bank, has worked.

Harshil’s rapid recovery has cheered stem cell transplant surgeons at Gujarat Cancer Research Institute (GCRI) where the first such transplant was performed nearly a year ago.

“This means that unrelated umbilical stem cell transplant can be termed as an established treatment. As they say, first success could be luck but second is science,” said director of bone marrow transplant department at GCRI Dr Sandip A Shah. The transplant was assisted by Dr Kinnari Patel and Dr Kamlesh Shah.

The first success story was of Rishi, a thalassemic major child from Kutch, who was cured by umbilical cord stem cells transplanted from an unrelated donor as he did not have siblings. Harshil is also the only child of his parents.

“While it took three months in Rishi for the donor blood cells to completely take over and change his blood group, Harshil has recovered within two months,” said Dr Shah.

For children without siblings and suffering from thalassemia, aplastic anaemia and similar blood problems, this is good news. The success rate of such transplants is 70 per cent.

Doctors are now poised to perform a third unrelated umbilical cord stem cell transplant. “The third patient is a girl called Zeel, who has got Rs 10 lakh as donation from Bollywood star Ajay Devgan to perform the transplant,” said Dr Shah.


Friday, November 20, 2009

Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation

Abstract

Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for breast cancer in the general population.

Methods: The USPSTF examined the evidence on the efficacy of 5 screening modalities in reducing mortality from breast cancer: film mammography, clinical breast examination, breast self-examination, digital mammography, and magnetic resonance imaging in order to update the 2002 recommendation. To accomplish this update, the USPSTF commissioned 2 studies: 1) a targeted systematic evidence review of 6 selected questions relating to benefits and harms of screening, and 2) a decision analysis that used population modeling techniques to compare the expected health outcomes and resource requirements of starting and ending mammography screening at different ages and using annual versus biennial screening intervals.

Recommendations: The USPSTF recommends against routine screening mammography in women aged 40 to 49 years. The decision to start regular, biennial screening mammography before the age of 50 years should be an individual one and take into account patient context, including the patient's values regarding specific benefits and harms. (Grade C recommendation)

The USPSTF recommends biennial screening mammography for women between the ages of 50 and 74 years. (Grade B recommendation)

The USPSTF concludes that the current evidence is insufficient to assess the additional benefits and harms of screening mammography in women 75 years or older. (I statement)

The USPSTF concludes that the current evidence is insufficient to assess the additional benefits and harms of clinical breast examination beyond screening mammography in women 40 years or older. (I statement)

The USPSTF recommends against clinicians teaching women how to perform breast self-examination. (Grade D recommendation)

The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer. (I statement)

Saturday, October 17, 2009

Happy Diwali

Dear readers, wishing you a very happy diwali and a great new year

Monday, August 31, 2009

Two doctors: Hysterias and Posteriors

""Two doctors, a psychiatrist and a proctologist, opened an office in a
small town and put up a sign reading: "Dr. Smith and Dr. Jones: Hysterias
and Posteriors"

The town council was not happy with the sign, so the doctors changed it to
read, "Schizoids and Hemorrhoids."

This was not acceptable either, so in an effort to satisfy the council,
they changed the sign to "Catatonics and High Colonic'."

No go. Next, they tried "Manic Depressives and Anal Retentive's." Thumbs
down again.

Then came "Minds and Behinds." Still no good.

Another attempt resulted in "Lost Souls and Butt Holes." Unacceptable
again!

So they tried "Analysis and Anal Cysts." Not a chance.

"Nuts and Butts?" No way.

"Freaks and Cheeks?" Still no go.

"Loons and Moons?" Forget it.

Almost at their wit's end, the doctors finally came up with:
"Dr. Smith and Dr. Jones, Odds and Ends."

Everyone loved it !!!""

with thanks to Dr. Sita Bhatt from her posting in forum at pathoindia.com

Sunday, August 30, 2009

Kayser-Fleischer ring


Kayser-Fleischer rings (KF rings) are rings that appear to encircle the iris of the eye. They are due to copper deposition as a result of particular liver diseases.

Appearance-The rings, which consist of copper deposits where the cornea meets the sclera, in Descemet's membrane, first appear as a crescent at the top of the cornea. Eventually, a second crescent forms below, at 6 o'clock, and ultimately completely encircles the cornea.

C/F- abnormalities of the basal ganglia of the brain, liver cirrhosis, splenomegaly, involuntary movements, muscle rigidity, psychiatric disturbances, dystonia and dysphagia. The combination of neurological symptoms, a low blood ceruloplasmin level and KF rings is diagnostic of Wilson's disease
Other causes- cholestasis (obstruction of the bile ducts), primary biliary cirrhosis and "cryptogenic" cirrhosis.

lesson to learn- KF rings r not seen only in wilsons disease, it can also be seen in chronic liver diseases.
Serum ceruloplasmin- 27-37mg/dl.
Serum copper- 70-140ug/dl

Sunday, August 16, 2009

What is protocols before thyroid function test in known thyroid pt on medicine?

Is there any need of stop medicine in patient taking external thyroxin [eg. eltroxin] before blood is drawn for a thyroxine function test.?

What should precautions be taken before sample collection for TFT?

please gives yours comments....

Wednesday, August 12, 2009

Toxic granules and Polymorph count (updated)

What is more important in predicting acute bacterial infection?

presence of toxic granules or
neutrophilia

many patients have neutrophilia without any changes in granules while some patients presents with toxic granules in neutrophils with normal counts
In my personal observation most patients with toxic granules in neutrophils also have increased numbers of large granular lymphocytes, does it suggest some specific group of infections?


kindly give your comments...

Tuesday, July 14, 2009

Exam Papers - 4

Paper 4 - Recent Advances
Marks - 100

Q. 1 Describe recent advances in salivary gland tumors. Discuss role of FNAC and Histopathology in diagnosing various lesions of salivary glands. -30

Q. 2 Discuss about blastemal tumors. Discuss recent updates with clinical significance. -30

Q. 3 Write notes on: -20

a) IHC in breast tumors.
b) Frozen section versus FNAC

Q. 4 Write notes on: -20

a) Newer techniques and instruments in hormone assessment.
b) Recent advances in blood-banking.

Exam Papers - 3

Paper 3 - Pathology including hematology
Marks - 100

Q. 1 Discuss storage disorders and diagnostic approach of it with clinical presentation. -30

Q. 2 Types of Hemolytic Anemia - Investigations in a case of hemolytic anemia.

Q. 3 Write notes on:

a) Parasites in hematology
b) Investigations in case of DIC

Q. 4 Write notes on:

a) Differential diagnosis of a case of thrombocytopenia.
b) Parameters and clinical significance of complete hemogram.

Friday, July 10, 2009

Exam Papers-2

Paper-II: Pathology and Immunology
Marks: 100

Q. 1 - Discuss role of image guided FNAC in intra-abdominal lesions. -30

Q. 2 - Describe diagnostic approach of SLE with clinical significance. Describe morphology of organs affected by SLE. -30

Q. 3 - Write notes on: -20
a) Secondaries in bone
b) Classification and diagnosis of amyloidosis

Q. 4 - Write notes on: -20
a) Gross- pathology of kidney and ovary
b) Graft versus host reaction

Tuesday, July 7, 2009

Exam papers

I have planned to post my PG exam papers here, there are total 4 theory papers I am posting the first in this post

Paper - I : Applied Basic Medical Science
total marks - 100

Q.1 Describe normal anatomy of brain. Give details of primary CNS lymphoma with clinical significance. - 30

Q.2 Describe thyroid function test with its clinical significance. Discuss diagnostic controversies in thyroid lesions. - 30

Q.3 Write notes on: - 20

1) S. Electrolytes - methods of measurement with clinical significance.

2) Body fluid examination with significance of ADA.

Q.4 Write notes on: - 20

1) Significance of PT and aPTT

2) HbA1c

Wednesday, June 17, 2009

spot it -8: answers

As indicated in comments, first one is aspergillus, with relatively uniform diameter and 45 degree branching ( acute angle branching), second one is mucormycosis having variable diameter of hyphae and mostly 90 degree branching

Friday, June 12, 2009

Spot it-8


Identify this two different fungi

Thursday, June 4, 2009

Spot it-7 :answer

Both images are of budding yeast forms, first one shows tear drop shaped budding suggestive of cryptococcus, while second image shows broad based budding suggestive of blastomycosis.

Monday, June 1, 2009

Spot it-7


Identify this two fungus, you can give your comments

Thursday, May 21, 2009

Spot it 6: answer

Though they look like but these cells are NOT squamous cells. If we see carefully these cells are having geometric profiles, many have square or quadrangular appearance, characteristic feature of plant cells, contaminating the specimen.

Tuesday, May 19, 2009

Spot it 6


This is a image from sputum, a very interesting one, can you identify this cells??
I will post answer after two days

Saturday, May 16, 2009

Spot it 5: Answer

This image is of Toxoplasma myocarditis, showing encysted bradyzoites of Toxoplasma gondi

Thursday, May 14, 2009

Spot it-5

This image is from heart

Saturday, May 9, 2009

Breast FNAC - Probabilistic approach

Breast FNA is more sensitive and specific for malignant neoplasms than for borderline or benign lesions. A diagnostic approach based on the probability of identifying malignancy in a breast is therefore more clinically appropriate. This has been termed the probabilistic approach to the diagnosis of carcinoma.

Five diagnostic categories are defined

1) Positive for carcinoma

all four of the following must met:

Cellular dyshesion
Cytological atypia
Single cell population
Hypercellularity

2)Suspicious for carcinoma

When any three of the above four features are present

3)Epithelial proliferative lesion with atypia

when the specimen in cellular with many epithelial cells and when epithelial cells present in groups and show significant crowding and overlapping and/or specimen shows one other feature of malignancy out of above four.

4) Epithelial proliferative lesion without atypia

when specimen is cellular with many epithelial cell and the epithelial cells in groups show no or mild crowding and overlapping, with obvious myoepithelial cells present and no other features of carcinoma.

5) Unremarkable

when none of the four features of malignancy is present

Tuesday, May 5, 2009

Spot it 4: Answer

Hi friends, this picture is of embryoid body from polyembryoma, a type of mixed germ cell tumor in which embryonal and yolk sac component combine to form structure resembling developing embryo (embryoid body)

Sunday, May 3, 2009

Spot it-4

Image from Ovary

Thursday, April 30, 2009

Spot it-3: Answer

Both are benign,

First figure shows radiation change, enlarged cells with low N:C ratio and smudgy chromatin is typical of radiation change

Second figure shows degenerative change, as evident by karyorrhexis

Tuesday, April 28, 2009

My Ubuntu Desktop!!



My Ubuntu desktop, click on picture to see in full view and tell me isnt it better than vista? Above all absolutely free, no virus, no spyware, and this is running on old celeron processor 512 MB ram and yet I dont feel any sluggish move!!

It contains following on screen

Gmail notifier
Pidgin messenger- combines multiple accounts of yahoo, gmail, msn etc.,
you tube
Google map
calculator
system monitor
main menu
net traffic monitor
window switcher
battery monitor
volume control
calender
digital clock
Gadget Panel with all stocks (first pic)

Monday, April 27, 2009

Spot it-3: benigh or malignant



This two are bronchial brush PAP stained preparation from different cases, what do you think are they benign or malignant? give your comments separately for both images.

Correct answer will be posted after 2 days

Spot it 1 and 2- answer

Spot it 2: these are charcot layden crystals in sputum, formed due to disintegration of eosinophilic granules , they can be seen in allergic pulmonary conditions including asthma



Spot It- This are sputum images showing curschmann spiral , they can be considered as mucus casts formed in bronchioles due to obstruction, can be seen in asthma, chronic smokers and other causes of obstruction

Saturday, April 25, 2009

Spot it-2

Give your comments, I will post correct answer after 2 days

Spot It!


Hi, friends give your comments on this picture, correct answer will be posted after 2 days

Monday, April 20, 2009

Premalignant Conditions of Breast


This is a seminar by one of my colleague, gives very basic understanding of breast pathology in lucid manner, will be very useful for new comer to pathology

LINK

Friday, April 17, 2009

WHO laboratory services in Tuberculosis control

Lab services in tuberculosis control provides basic guidelines for health care laboratories about specimen handling, staining, culture and identifcation of mycobacteria in simple step by step manner with colour photographs

Wednesday, April 15, 2009

Biomedical Waste Disposal Rules India

In light of recent outbreak of Hepatitis B in Modasa, Gujarat due to improper waste disposal by medical professionals and use of used syringes and needles. Which was followed by finding of used syringe storage at many cities in Gujarat. It is important to know the current laws regarding waste disposal in India

I am uploading here Waste disposal rules, 1998 amended 2000 under the environmental act, 1968 in PDF format

It may be useful as a guide to waste disposal for those practicing outside India

LINK

Saturday, April 11, 2009

Medpedia

this is more reliable brother of wikipedia, there are so many ways to contribute and share knowledge there, here is what they say about

Ways to make medpedia work for you:

Get listed in Medpedia by creating professional and be known in your area of expertise

Get recognized for you professional by creating and editing medical encyclopedi in your area of expertise

Build your professional network


Get credited forever as "originating author" by creating new article

Ask questions and share insights with peers in group discussions

So join it, and start sharing knowledge, as medipedia is yet in childhood, your services will be invaluable

By joining as a medical professional you can edit and create new articles

Only doctors are allowed to edit or create articles as opposed to wikipedia, so it is more reliable

Friday, April 10, 2009

flow cytometry

A brief and concise ppt. about general principles and uses of flow cytometry.

Laboratory Diagnosis of Malaria

I prepared this during my first year of residency, It covers following

Microscopic tests
  • Peripheral smear
  • Quantitative buffy coat
Non microscopic tests
  • Immunochromatographic tests (rapid tests)
  • Antibody detection
  • flow cytometry
  • mass spectometry
  • PCR

It is in DOC format

LINK

Thursday, April 9, 2009

FISH- from basics to advanced.


This was a presentation by one of my senior on basics of FISH. A very fine, simple but exhaustive detailing about the technique. enjoy.

Tuesday, April 7, 2009

Gastrointestinal Stromal Tumors-recent


This is first seminar that I prepared during my first year of residency, It is in powerpoint format

http://ifile.it/uh4fkn2

Monday, April 6, 2009

Way of teaching/learning?

This quote is directly from Neuropathology Blog of Dr. Brian E. Moore, just think it in Indian scenario

"After my recent lecture on infections of the CNS, Southern Illinois University medical student Mike Sinha came up to the podium to ask why the herpes virus had a predilection for attacking the temporal lobes. I passed Mike's question on to Dr. Tom Smith, the neuropathologist who provided the photographs (see above) of herpes encephalitis for Robbins and Cotran Pathologic Basis of Disease (7th edition). Dr. Smith wrote that the question is not completely resolved, but he directed me to a 2002 review article which addressed the issue (Journal of Neurology Neurosurgery and Psychiatry 2002;73:237-238). I quote from that article:

"Regarding the site specificity of herpes simplex encephalitis (HSE), the pathway of viral spread is probably more important than cell-type viral susceptibility. The unique anatomical localisation has been thought to result from entry of the virus via the olfactory pathway with spread along the base of the brain to the temporal lobes, a view that is supported by the immunocytochemical evidence of HSV antigens in the olfactory tract and cortex, as well as temporal lobes, hippocampus, amygdaloid nucleus, insula, and cingulate gyrus in patients dying from HSE. Another suggestion is that HSE may result from viral spread from the trigeminal ganglia to the temporal and frontal cortex, a view that is consistent with this known site of HSV latency."

Thanks to Mike Sinha for a provocative question and to Tom Smith for researching the response."


How many of Indian teacher will take such provocative question in positive way?? As per my experience such student will be fired by most of our teachers. Dont we need a change??

Saturday, April 4, 2009

Medical Algorithm

I found this site while searching for a semen counting method

A Medical Algorithm is any computation, formula, survey, or look-up table, useful in healthcare. More than 10141 algorithms, organized into 45 chapters, are available as spreadsheets on this site, along with direct pubmed search feature for the algorithm

This site is powered by non profit organization institution of algorithmic medicine.

Worth have a look, as this site provides very extensive list of complete algorithms, for example, there are 10 different formulas to differentiate iron deficiency from thalassemia!!

Friday, April 3, 2009

World Health Organization Classification of Tumors Hematopoetic and Lymphoid


Example of what I have said in previous post about how to download books from, books.google.com

If you like kindly purchase the book

If you feel that your copyright is broken, inform the author with your positive identification as copyright holder and post will be removed

Wednesday, April 1, 2009

Post Mortem Technique


Are you tired of reading oldies like Otto Saphire, try this one to get latest in post mortem

Note: for pathologists, may also be useful for forensic people

If you like kindly purchase the book

If you feel that your copyright is broken, inform the author with your positive identification as copyright holder and post will be removed

Tuesday, March 31, 2009

Sentinel Lymph Node Mapping-Pathology Protocol.

Topics include :

1. Definition of Sentinel Lymph node
2. Procedure of Sentinel LN
3. How to process and report sentinel LN
4. What is significance

New Pathology Links

Dear friends, we have added 4 New links in our Great Pathology Sites (in right side panel), have a look and give your comments

Digital Atlas of Breast Pathology
Digital Atlas of Gynecological Pathology
Pathology Images
Oncopathology Blog

Monday, March 30, 2009

Renal biopsy- a short note

it's in a short about various procedures which are in use to perform renal biopsy. dedicated to the exam goings.

all u want to know about investigating male infertility

hi, especially, to all my juniors who r going to appear in the pg exams.
While searching for testicular biopsy i stumbled upon this article on evaluation of male infertility, and found it both interesting as well as informative and recent. if u have lots of leisure time :0 then take a look at it.

Thursday, March 26, 2009

Dear subscribers

As I am appearing in my PG exam next month I want be able to post new material for about one month from now, see you soon...

btw. other authors will keep posting

-sharad

Monday, March 23, 2009

PATHOINDIA


There r very few sites, one finds interesting on the first look and later become a fan of it. One of them is pathoindia.com.The case discussions and reviews of the slides is very informative. One thing, which i like most about it, is that u can also give ur opinion on the slides, and then compare with other pathologists' view. try it out, u will find it interesting too...

Sunday, March 22, 2009

How to download google books



Recently I have found a way to download Google books, which I am sharing here, this is for educational purpose only(for google too!!)
After extensive searching I found three ways, two of them no longer works or didn't work for me, first is a software called Google book downloader which is suppose to download books in PDF format, I tried its recent GBD-0.1.0.alpha8 version but it didn't work for me, second I tried a website leechvideo which again didn't work.

Idea which worked successfully is this

First of all you need Firefox, IE doesnt work

Then install add on Greasemonkey , search through firefox add on, you should easily find this, it allows you to run various screepts through your browser, which can modify appearance of websites, after complete installation icon will appear on lower right of your browser

Now you will need a script called [ Userscript ] Google Book Downloader, after installing this script whenever you will open the google books site, you will find a download button on upper right hand corner, click on it, it will list all the availabe pages of the books

Then one last plugin called FlashGot, this will download all the pages you have selected, just rignt click after selecting the pages and then click FlashGot Selected, or click FlashGot all for all pages


TRAPS IN this method: there are few points where you might get trapped,

dont try to install userscript before installing greasymonkey

dont search for books from www.google.com, because links generated is not compatible with this method, rather go direcly to http://books.google.com

In flashGot options select "browser built in", option rather than w-get

Downloaded pages are saved without extension (i.e, *.jpg, *.png), google uses either jpg or png format randomly for different pages in the same book, so you will have to apply correct extension by trial and error method(tiring thing) before you will be able to open the page in windows, If you are using UBUNTU, all pages can be opened without extension because Ubuntu recongnises format without using extension as windows does

converting to PDF with acrobat pro will require the correct extension behind name of every picture file generated even if you are using Ubuntu, but this is easier with Ubuntu as file property will tell you the correct format

and last thing you can download only available pages , so search for only full view books

All the best, dont forget to comment about your experience, your suggestion are welcome

Tuesday, March 17, 2009

Benigh mimics of Urothelial Malignancies


This is a presentation prepared from combined material from various sources, describing urothelial neoplasms, their benign mimics and differential diagnosis

Link

If you feel that your copyright is broken, inform the author with your positive identification as copyright holder and post will be removed

Thursday, March 12, 2009

Bethesda system for Thyroid FNAC

This is a powerpoint file of a lecture by Dr Ed Cibas, from November 2008, describing the latest and final version of The Bethesda Thyroid FNA Terminology and Classification that will be appearing in the Bethesda Thyroid FNA Slide Atlas, to be published by Springer in the autumn (fall) of 2009. The presentation describes how the final decisions about the Bethesda Thyroid FNA terminology were made and some of the reasoning behind the various names adopted for the different FNA categories in the Bethesda Thyroid FNA System. The content of this lecture also supersedes what the Bethesda working group have previously published on the conference website and also in the various articles in Diagnostic Cytopathology in June 2008

LINK

Tuesday, March 10, 2009

Webpathology


High quality histopathology images, organised by system, currently includes genitourinary system, lymphnodes and spleen. Image quality is excellent

Link

California tumor tissue registry


This site provides new Histopathology case study every month with detailed case history, discussion, differential diagnosis and high quality photographs

You can see older case studies by searching months name in search box provide e.g., search for "october 2008" to look for case study of oct. 2008.

Link

Sunday, March 8, 2009

WHO books- full view

Who books, with latest classification of tumors, along with detailed histopathology, clinical features, genetics and in some cases cytology is available on google books for online view

LINK

Friday, March 6, 2009

Good news for Doctors

Whenever a consumer forum or a criminal court receives a complaint against a doctor, it should refer the matter to a panel of experts. Only after the committee reports that there is a prima facie case of medical negligence should a notice be issued to the doctor or hospital concerned.

This is necessary to avoid harassment to doctors who may not be ultimately found to be negligent. Courts and consumer fora are not experts in medical science and must not hold their own views over that of specialists.

The court also warned police officials not to arrest or harass doctors unless the facts were in line with earlier apex court guidelines. Otherwise the policemen will themselves have to face legal action.

Indian Journal of Medical Ethics


Times of India

Wednesday, March 4, 2009

Bakwas about slumdog


"THIS ARTICLE IS NOTHING BUT AND ATTEMPT TO GAIN A CHEAP PUBLICITY BY CRITICIZING A POPULAR AND WELL MADE MOVIE, JUST LIKE RAJ THAKRE ATTACKING AMITABH BACHCHAN", there are so many worse thing to criticize but why people choose only popular things, and unfortunately this movie shows only truth, there is nothing to critisize there man!!

For some people it is hard to believe that foreigners can create good movie about India and become popular, but the truth is truth, the first thing that came to my mind after reading the article is, Raj thakre trying to throw out non marathi's out of maharashtra, and criticizing Jaya bachchhan just for a shake of being in news. This mentality should change, cant we accept the simple truth.., slums are there, and reality is probably worse than shown in movie, No one becomes carorepati so easily, just accept that
I dont know why person like Arindam is running after such cheap publicity, I just want to ask, Are you going to join politics??


UPDATE: Phot of child selling Sunday Indian- Arindam's brand, Who opposes slumdog millionaire for showing poverty and child abuse in India

Link to Arindam's post

Wednesday, February 25, 2009

Pathological Case Studies


These two sites provides case studies with pathological view, IPLAB is good for undergraduates with cases in general pathology format, while UNIVERSITY OF VIRGINIA provides nice case studies and discussions for pathologists and pathology residents

IPLAB

UNIVERSITY OF VIRGINIA, PATHOLOGY SITE

Tuesday, February 24, 2009

Best Medical Websites - user ratings




Amedeo´s Golden Links propose a collection of outstanding medical websites. The websites are ranked by quarterly polls taken from members of the Amedeo Literature Service.

Golden links 4 Doctors

Monday, February 23, 2009

USCAP





United states and Canadian academy of pathologists have created great site, it offers lots of EDUCATIONAL MATERIAL and VIRTUAL SLIDES OF HISTOPATHOLOGY

best of pathology available online

USCAP

Sunday, February 22, 2009

Histopathology Slides Study




Hi, IOWA university pathology department has put very nice collection of histopathology virtual slides on net. It will be very useful to all pathology residents and pathologists.

Viewing requires Java 1.5, latest java 6 is not supported, You will have to downgrade your java version or keep both version together, but site is worth it

LINK

Friday, February 20, 2009

use UBUNTU, throw away WINDOWS






UBUNTU is great open source free operating system

You can order free installation CD directly from owners or download from their site

It is VIRUS FREE

Easy to use, faster, most needed softwares are freely available from their original site

NO PIRATED SOFTWARES ARE NEEDED

IT SUPPORTS MOST WINDOWS PROGRAMMES, THROUGH WINE WINDOWS COMPATIBILITY LAYER

You will be saved from frequent formating of you hard disk

Great user forum to help and answer your all questions

It is also works with older computer, with low RAM and small hard disk, installation required only 2 GB as compared to about 7 GB with vista

If u have doubt try it on other partition with windows

You can post comments if any query

Get it now - it is great

Great cytology sites


Some of the best cytology sites you ever get to see



John-Hopkins - cytology case studies, image atlas and lot more (above image)

Cytology stuff - good for cervical and fluid cytology, also cells blocks

How to read books on computer




hi friends,

I prefer PDF format for books, because u can underline or highlight the important points with adobe acrobat professional. U can also write new comments with typewriter tool, use photgraphs in ur presentations ( CHM does not allow any of this function).

If u have book in CHM convert it to PDF using CHM2PDF converter.

If PDF is password protected use advanced pdf password remover to allow marking/editing

Java downloader



Java downloader is a free open source plateform independent downloader programme that accepts multiple links and downloads them one by one automatically, it supports most download sites like RAPIDSHARE, MEGAUPLOAD etc..

It is good for both free users and premium users

here is the link

JDOWNLOADER - original site

ENJOY...