Eccrine Spiradenoma - Images

There were multiple nodules like this, in this case

Two type of cells, dark ones in periphery, light ones in centre. Cells are arranged around small lumina containing eosinophilic material.

Well circumscribed and not attached to epidermis

Eosinophilic material prominent here.

Cystic changes are seen in some (degenerative or ancient changes)

Lymphocytic infilteration is common in this tumor.

Case - ?lipid storage

Male 12 year, presented with severe anemia, moderate splenomegaly, moderate hepatomegaly, PS shows microcytic hypochromic anemia (Hb 3.5), with rouleaux formation, platelet low normal, total count appear low normal with neutrophils 70%. BM examination done 3 days after first BT given on the day of admission. cilincally ??acute leukemia. On bone marrow, there was mild erythroid hyperplasia, prominent toxic granulation in neutrophilic precursors. No significant number of blasts. Megakaryocytes appear within normal limits. Now after almost ruling out acute leukemia, second clinical possibility remains is of ?lipid storage or ?some chronic infection. I am posting few pictures here, does it suggest any storage disorder or just arteffects. Kindly give your opinions. I feel it is some chronic infection, but not sure. MP negative by slide and card. Kindly give your comments. Will try to post more pictures soon.

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Sudden Sniffing Death Syndrome

At age 12, most kids are concerned with finding a ride to the movies and making it through middle school. Ashley Upchurch was younger -- 11 -- when she became addicted to inhaling air dusters as a way to get high. 

"It was a cheap high, it was instant, and it was intense," Upchurch, now 17 and sober for over two years, said today in a Washington D.C. seminar about the danger inhalants pose to children. 

New data released today by the Substance Abuse and Mental Health Services Administration (SAMHSA) indicates that 12-year-old kids are more likely to get high from common, legal household substances including aerosol computer cleaners, air fresheners, hair spray or shoe polish than use cigarettes or marijuana. 

Stem Cells May Provide Vaccine For Colon Cancer

Immunology experts in the US and China have discovered human stem cells that "fool" the immune system may provide a vaccination for colon cancer.

The study was led by Dr. Bei Liu and Dr. Zihai Li in collaboration with stem cell expert Dr. Renhe Xu at the University of Connecticut Stem Cell Institute and is to be published in the journal Stem Cells.

The study builds on an old notion that immunizing with embryonic materials might produce anti-tumor responses, but this has only been shown in animal studies.

AIDS virus can hide in bone marrow

The virus that causes AIDS can hide in the bone marrow, avoiding drugs and later awakening to cause illness, according to new research that could point the way toward better treatments for the disease.

Finding that hide-out is a first step, but years of research lie ahead.

Dr. Kathleen Collins of the University of Michigan and her colleagues report in this week's edition of the journal Nature Medicine that the HIV virus can infect long-lived bone marrow cells that eventually convert into blood cells.

The virus is dormant in the bone marrow cells, she said, but when those progenitor cells develop into blood cells, it can be reactivated and cause renewed infection. The virus kills the new blood cells and then moves on to infect other cells, said.

Gut Bacteria May Spur Obesity, Research Suggests

Intestinal bacteria may contribute to obesity and metabolic syndrome, a new study in mice suggests.

"It has been assumed that the obesity epidemic in the developed world is driven by an increasingly sedentary lifestyle and the abundance of low-cost, high-calorie foods. However, our results suggest that excess caloric consumption is not only a result of undisciplined eating but that intestinal bacteria contribute to changes in appetite and metabolism," senior study author Andrew Gewirtz, an associate professor of pathology and laboratory medicine at Emory University School of Medicine, said in a university news release.

Tuberculosis, Fourth Edition: The Essentials

Edited by Dr. Mario C. Raviglione, Director of the World Health Organization’s(WHO) Stop TB Department, the Fourth Edition presents key updates on recent discoveries and studies in tuberculosis (TB) detection, treatment, and prevention, to give pulmonologists, infectious disease specialists, and research scientists the tools they need to provide better patient care and develop new paths of TB research.